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Hi all,

Please spead this around to people you think needs to know, it's finally been proven that SA is NOT inherited by a

simple recessive, it's a lot more complcated than that. This is what most of us have felt during all these years.

I have just received this info and I thought you might find it interesting in case you hadn't already heard.

Anders

http://standardpoodleclub.com/welfare-news.html or look below:

 

Animal Health Trust

Lay Summary of Progress Report To Determine Genomic Region Associated with Sebaceous Adenitis in the Standard Poodle

Sebaceous Adenitis (SA) is a dermatological condition that has been described in several breeds of dog, most commonly in the

Standard Poodle. It is a condition in which the sebaceous glands in the skin become inflamed and are eventually destroyed, l

eading to hair loss and secondary skin infections, and is a significant health and welfare problem.

The Animal Health Trust has collected DNA samples from over 300 Standard Poodles. Using the latest genotyping techniques,

(a Canine SNP(single nucleotide polymorphism) array of 22,362 genome-wide SNPs) we have genotyped a subset of 48 samples

from dogs with a rigorous SA diagnosis, which included 20 affected dogs and 28 unaffected dogs. We have been helped enormously

by the Standard Poodle Club UK in this choice of samples. Using this data, we have carried out careful computer analysis to try to

identify the region in which the SA mutation lies.

The preparation of the DNA samples and their genotyping have been achieved successfully. All 48 samples were genetyped,

although 4 fell below rigorous acceptability standards and were not included in the analysis.

The vast majority of the 22,362 SNPs on the array (over99.7%) worked well this is a very impressive result.

The data was analysed using pedigree-based linkage software and association-based software. The analyses were carried out

successfully: we know this because using identical methods on other diseases and breeds, we have been able to identify genome

locations linked to the diseases. However for the Standard Poodle samples both types of analysis failed to identify any regions of

the genome which were significantly associated with the disease.

We are confident that the genotyping data we generated was of a very high quality, so the likely explanation of our failure to

identify a region of the genome associated with SA is because the disease is complex, and is either caused by more than one gene,

or the interaction between gene(s) and the enviroment. Alternatively, our controls included a number of subclinically affected dogs whose

skin biopsy results lead us to mis-categorise them. In either case, the solution is to collect and genotype more samples, and any new

data can be added to what we already have, thus increasing the chances of success.

This is a disappointing result, but as a result of this investigation we now can say fairly confidently that sebaceous adenitis in

the Standard Poodle is not inherited as a simple autosomal recessive with a high degree of penetrance, and that more samples

need to be analysed to identify a genomic region associated with the disease.

We are committed to continuing our study of SA in the Standard Poodle and will continue to collect and store samples to successfully

analyse SA as a complex trait. Data generated during the current study will be saved, and added to additional data generated in

this subsequent phase of the study.

Co-Principal Investigators: Cathryn S Mellersh and Mike Boursnell.
Animal Health Trust, Newmarket.

 

 

 

 

Poodle Petition August 2009